1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid - Names and Identifiers

Name	1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid
Synonyms	1H-Pyrazolo[3,4-b]pyridin-3-carboxylic acid 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid 1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid 1H-Pyrazolo[3,4-b]pyridine-3-carboxylic acid 2h-pyrazolo[3,4-b]pyridine-3-carboxylic Acid 1H-Pyrazolo[3,4-b]pyridine-3-carboxylicacid(9CI)
CAS	116855-08-4
InChI	InChI=1/C7H5N3O2/c11-7(12)5-4-2-1-3-8-6(4)10-9-5/h1-3H,(H,11,12)(H,8,9,10)

1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid - Physico-chemical Properties

Molecular Formula	C7H5N3O2
Molar Mass	163.13
Density	1.68
Melting Point	265-270℃ (DEC.)
Boling Point	391.1±25.0 °C(Predicted)
Flash Point	241.107°C
Vapor Presure	0mmHg at 25°C
Appearance	Solid
pKa	8.83±0.20(Predicted)
Storage Condition	2-8°C
Refractive Index	1.763
MDL	MFCD11040725

1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid - Risk and Safety

Risk Codes	20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S24/25 - Avoid contact with skin and eyes. S36/37 - Wear suitable protective clothing and gloves.
HS Code	29339900

1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid - Reference Information

Use

1H-pyrazolyl [3,4-B] pyridine-3-carboxylic acid is a carboxylic acid derivative, it can be used as an intermediate in the synthesis of medicine and in the experimental research of medicine.

preparation

at room temperature, A mass of 2-chloro-3-acetylpyridine was added to the condenser tube and an electrically stirred three-necked flask, and hydrazine hydrate was added as a solvent. The reaction was stirred in organic solvent for 1 hour, heated to reflux overnight, and the reaction progress was detected by thin layer chromatography. When the reaction was finished, the temperature was stopped, and the system was cooled to room temperature, then purified water and dichloromethane were added, the reaction solution was extracted, and the organic phase was collected after standing and stratification, and the aqueous phase was washed many times. After the organic phase was combined, anhydrous sodium sulfate was added to dry, and the organic phase was concentrated and purified by silica gel column chromatography, the compound 1H-pyrazolyl [3,4-B] pyridine-3-carboxylic acid was obtained.

Last Update：2024-04-09 20:52:54